Testosterone Replacement Therapy: Skating on Thin Ice?

A recent VA study published in JAMA indicated that men taking testosterone replacement therapy had a 29% increased risk of stoke, MI and death. The VA study was observational, not a clinical trial, so it’s findings are of limited scope, but as there are now over 5-million prescriptions for testosterone therapy given in the US every year, the study ought to sober up the increasingly rowdy testosterone replacement party. There are naysayers to the study, including the Life Extension Foundation (LEF). I was asked to review the VA/JAMA article and the LEF rebuttal. Below is my analysis. Continue reading “Testosterone Replacement Therapy: Skating on Thin Ice?”