Low Dose Naltrexone (LDN) In the Management of Autoimmune Conditions

Conventional Naltrexone

What is Naltrexone?
Naltrexone is a drug that is typically used at “full” dose for opioid addiction or overdose. When naltrexone is taken at a much lower dose, patients with autoimmune conditions may experience significant benefits in symptom reduction, improved lab markers, and slowed or reversed disease progression. The therapeutic dose of low-dose Naltrexone for autoimmune conditions is typically between 3.0mg – 4.5mg. Conditions that may benefit from LDN include: lupus (SLE), rheumatoid arthritis, Crohn’s, ulcerative colitis, MS, fibromyalgia, chronic fatigue syndrome, celiac, psoriasis, Sjogren’s, scleroderma.

How does LDN work?
Low doses of Naltrexone taken at temporarily block your opioid receptors. This signals your brain that your levels are low, then your body responds by ramping up the production of endorphins. This surge of endorphins (and opiate receptors) can modulate your immune system and decrease autoimmune symptoms.

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Celiac Disease and Non-Celiac Gluten Sensitivity: What Flavor of Gluten-Free Consumer Are You?

Percent of US going gluten freeGluten = Gliadin + GluteninGluten. There is wave of gluten avoidance sweeping around the modern world. 22% of Americans currently follow a gluten-free diet, compared to 15% in 2013. In 2014, consumers spent $8.8 billion on gluten-free products — an increase of 63% from 2012

So what is gluten? Gluten is a mix of two proteins (gliadin + glutenin) found in the Triticeae family of grains including wheat, barley and rye.

Evolutionary Tree of Wheat.jpg

Alpha-gliadin is the problematic part of gluten, and we know have a pretty good idea why this is. There are now two well defined medical conditions where gluten avoidance is a medical necessity. These are celiac disease (CD) and non-celiac gluten sensitivity (NCGS). Whether or not you have true celiac disease CD or NCGS, there are some very good reasons to avoid gluten. Continue reading “Celiac Disease and Non-Celiac Gluten Sensitivity: What Flavor of Gluten-Free Consumer Are You?”

When in Doubt, Treat the Gut: Elimination Diet, Probiotics, and Stool Testing

“Death begins in the colon” –Hippocrates

Modern processed food may be common, but to our bodies, the modern diet is an extraterrestrial encounter.

In humanity’s 200,000 year history, farming is an suprisingly new development. About11,000 years ago, agriculture started popping up around the globe in a few disconnected areas: Asia, South America, Europe and the Middle East (“The Fertile Crescent” in modern day Iraq and Syria). What this means is that for more than 90% of our development as a species, humans were not eating grains or or any modern farmed foods. Processed foods with refined sugars, refined grains, preservatives, artificial flavors, etc. are only 50-75 years old. This means that, at most, 99.3% of humanity’s evolution was apart from any processed food.


Historically speaking, the hominids from which humanity evolved ~5 million years old. This makes the development of processed food 99.999% foreign to us. Fast forward to the present. We all are living in a society where processed food has become the bizarre but pervasive normal. Continue reading “When in Doubt, Treat the Gut: Elimination Diet, Probiotics, and Stool Testing”