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The Onco-Metabolic State: How to Make Your Body Less Hospitable to Cancer

November 12, 2013

We are often told in medicine that cancer cells are a single cell that “went bad” and started making copies of itself without all the normal mechanisms that limit reproduction and promote adhesion. We know now that this is not entirely right. Cancer cells are primarily ones that have lost the ability to repair breaks and mutations in their DNA. In this way, they begin a kind of accelerated evolution and become a diverse set of rapidly changing (i.e. evolving) cells with different properties, and adapted to environments that promote cancer growth and inhibit the immune cells that would normally kill cancer cells. The conditions under which cancer cells generally thrive in can be called “The Onco-Metabolic State”.

“The Onco-Metabolic State” is characterized by:
1) High blood glucose, insulin, and lipids.
2) High inflammatory markers: CRP, COX, 5LOX, PGE2
3) Coagulation: High fibinogen, D-Dimer
4) Angiogenesis promoters: Copper, cellular growth factors (VEGF, EGF, PDGF)
5) Hormones: High armomtase enzyme activity, low-SHBG, high E2 (estrodiol)
6) Vitamins: Low A, D, E, K, CoQ10
7) Oxidation/antioxidants: Higher reactive oxugen species (ROS), low antioxidant intake
8) Immune deficiencies: High cortisol (from stress), high sugar intake, excess calories

With this knowledge in hand we can begin to identify what parts of the oncometabolic state exist in cancer patients and then do things to address these problems and make the body a less hospitable for cancer to thrive.

Goal–Reduce Inflammation
Measure CRP (C-reactive protein) Goal= <1.0
Elevated CRP correlates w: fatigue, poor quality of life, weight loss, shorter survival
Take fish oil with DHA/EPA
Eat more vegetarian and wild/grass-fed animal products, wild fish
Take Boswellia (herb) 5-Lipoxygenase inhibitor: 20-50 mg/kg/day.
Take bromelain 750mg TID: (BETWEEN MEALS):
Support adequate sleep (nose strips CPAP-machine) Apnea=bad!

Goal–Reduce stress, because stress promotes inflammation
Take Rhodiola. Eat foods that reduce the activity of NF-kb (nuclear factor-kappa beta)
…Black pepper, cinnamon, tumeric, rosemary, mango, clove, licorice…
Avoid Omega-6 fats: worst from grain/corn-fed cows, pigs and foul, farmed fish

Goal–Reduce Copper Levels
Test copper levels, if moderate or high, take action!
Compare to ceruloplasmin (Cp) levels. Cp is a copper binding enzyme
Formula to integrate the two measurements… Need to ask Dr. Jeanie
Why?? Copper promotes the initiation and migration of tumor cells
Easy: Zinc 50mg TID Short term (1-3 months then retest)
Medication: Tetrathiolmolbdate (chelates copper)
Acidic water + old copper pipes increase copper risk (filter!)
Many “good” multiple vitamins have some copper.

Goal–Test and raise Vitamin D3
Test Vitamin-D levels (goal = 50-80 ng/dl).
Take 100IU for every point you are looking to increase (up to 8,000 IU/day) for 1-3 months then retest.
If levels are not up, test for 1,25-dihydroxy-vitamin-D diversion.

Goal–Reduce Estrogens
Reduce estrogens with foods that reduce aromatase activity.
Foods that reduce aromatse activity include: cruciferous veggies, grapefruit, thai ginger, mung beans, rosemary thyme basil, (many more).

Goal–eat foods that are associated with remission
In studies of food frequency questionnaires with cancer patients, spontaneous regressions were associated with certain diet choices: 1988 Harold Foster, PhD the University of Victoria BC reviewed 200 cases of spontaneous regression 87% made major dietary changes:
Foods eaten more frequently: Broccoli, leeks, onions, cauliflower, brussel sprouts, carrots squash legumes apples pears.
Foods eaten less frequently: caned foods, frozen foods, commercially raised meat, smoked meats or fish, white sugar, table salt, alcohol.

With big thanks to one of *the best* speakers at the 2011 IFM Symposium:
Jeanne Wallace, PhD, CNC

trmorrisnd headshotDr. T.R. Morris is a licensed naturopathic medical doctor (ND). He is currently serving as faculty and consultant to the Institute for Functional Medicine (IFM). The IFM mission is to revolutionize medicine by teaching the latest genetic, nutritional, hormonal and other biochemically-based integrative medicine techniques to MDs and other practitioners looking for new tools to prevent and treat chronic disease. In the past, T.R. served as the medical director of a large integrative clinic and taught (genetics, physiology, biochemistry, microbiology, cellular & molecular biology) for 10 years for various medical programs in the Puget Sound. He sees patients in person (or long-distance via Skype consultations) from his home office in Seattle.
Contact Dr. Morris

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